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Vitamin D is a nutrient hormone although it's not a vitamin in the classic sense. Vitamin D exists as an inactive prohormone until it is metabolized within the body to a steroid hormone. Deficiencies of vitamin D have been found to contribute to various cancers and autoimmune diseases, particularly conditions of type 1 diabetes, multiple sclerosis, and psoriasis. Recent studies indicate that there’s a critical need for testing blood levels of vitamin D.
Sources of Vitamin D
About 80 percent of the body’s supply of vitamin D is produced photochemically when ultraviolet radiation from sunlight reacts with a precursor chemical found in the skin. The end product is vitamin D3 or cholecalciferol. The liver metabolizes vitamin D3 into calcidiol, which is the main form of vitamin D that circulates in the blood. The kidneys then convert calcidiol into compounds that bind with protein. Linked to protein, vitamin D travels to various organs within the body.
With age, the body’s ability to manufacture vitamin D declines. Sunblocks, cloud covers, and pollution also reduce absorption of vitamin D. Recent studies show that vitamin D deficiency is widespread, especially among minority groups. Levels of vitamin D are also low in celiac disease, Crohn’s disease, and in pancreatic enzyme insufficiency. Besides sunlight, vitamin D is available from cod liver oil, fatty fish, and vitamin D-fortified milk.
Functions of Vitamin D
Vitamin D maintains blood levels of both calcium and phosphorus. These minerals are essential for the support of normal neuromuscular function and skeletal mineralization. Without adequate vitamin D, calcium is leached from blood, causing rickets in children and osteomalacia in adults. In addition, low calcium levels (hypocalcemia) can lead to low levels of parathyroid hormone (hypoparathyroidism).
At the Cellular Level
At the cellular level, vitamin D supplementation can help prevent or reduce disease progression. In certain malignancies, such as prostate cancer, vitamin D acts as an anti-inflammatory agent by downregulating the enzyme cyclo-oxygenase II. Vitamin D also downregulates pro-inflammatory cytokines and increases levels of anti-inflammatory cytokines. In recent prostate cancer studies, the addition of vitamin D to chemotherapeutic agents resulted in markedly improved outcomes.
Vitamin D toxicity, does it exist ? Fear of toxicity by supplementing is unwarranted. Although it is true that vitamin D in excess poses the risk of toxicity, the medical community has yet to produce any evidence that 10,000 IU/day is toxic. It is important to remember that the normal human physiological response, when exposed to UVB rays, is to produce between 10,000-20,000 IU within thirty-minutes! So, what is considered excessive vitamin D intake? Animal data indicates that signs of toxicity can occur with ingestion of 20,000 IU/Kilogram, while the oral lethal dose that would kill half the animal in the study is 3,520,000 IU/Kilogram. How does this equate to humans? Well, after extrapolation of the data a 110-pound adult would have to take 176,000,000 IU or 17,600 tablets of Vitamin D10 in order to have a 50% chance of dying. Still not convinced? Let us consider something as safe as water. Eight glasses of water a day is consider recommended consumption for maintaining health. However, some individuals suffer from a harmful disorder known as compulsive water intoxication and will consume up to 40 glasses of water a day. This give water a therapeutic index, a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes death, of 5. Research indicates that healthy human utilize about 4,000 IU of vitamin D a day in order to maintain health; however, research also shows that 40,000 IU a day over several year would likely produce harm. So, vitamin D has a therapeutic index of 10-theoretically twice as safe as water, proving that vitamin D at the doses Mother Nature provides, 10,000 IU/day, is safe. Pivotal Health provides 10,000 I.U. of Vitamin D3 in a dose of two capsules, replicating natural vitamin D3 production in the body making it a safe and effective way to ensure optimal vitamin D levels. To read more information, check out the following link.
This information was written and approved by the Founders and CEO's of Synergy Therapeutics and Vitamin D10:
Dr. Nicholas Wyatt, PharmD
Director of Pharmacology, Liberty Bay Internal Medicine Assistance Medical Director, Liberty Bay Internal Medicine Director of Pharmacology, Synergy Therapeutics Rx Intensive Care Clinical Pharmacist, Harrison Medical Center Consultant Pharmacist, Practical Pharmacology Solutions Associate Clinical Professor, University of Washington School of Pharmacy
Narinder Duggal, MD, FRCPC
Receiving his medical degree from University of British Columbia School of Medicine, Dr Duggal received his board certification in Internal Medicine and a Fellowship of the Royal College of Physicians of Canada. A specialist in Clinical Pharmacy, Dr. Duggal is currently an active Medical Director, Attending Physician and Clinical Associate Professor for the school of Pharmacy at the University of Washington in Seattle, Medical and Pharmacological Consultant and Board Member of the Cardiac and Pulmonary Rehabilitation Institute as well as the Medical Director at Liberty Bay Internal Medicine and Synergy Therapeutics RX.
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International calls only 1-602-404-3384 Email: sales@pivotalhealth.info Serracor-NK andPrevialin-HS is not recommended for women who are pregnant or nursing as these groups have not been clinically tested. Anemic women with heavy periods should take Serracor-NK with caution, as additional bleeding can occur. Do not take Serracor-NK if your fibroids are causing immediate health concerns, or if you are currently taking blood thinning medication. As always, consult with your doctor before taking Serracor-NK.
